Changes in arterial stiffness, carotid intima-media thickness, and epicardial fat after L-thyroxine replacement therapy in hypothyroidism.
نویسندگان
چکیده
OBJECTIVE To assess the relationship between primary hypothyroidism and subclinical atherosclerosis and its potential changes with L-thyroxine replacement therapy. METHODS A prospective cohort study including 101 patients with primary hypothyroidism and 101 euthyroid patients as controls was conducted from July 2011 to December 2013. Clinical, anthropometrical, biochemical, and ultrasonographic parameters were assessed at baseline and after one year of L-thyroxine replacement therapy. RESULTS At baseline, hypothyroid patients had significantly greater values of blood pressure, total cholesterol, VLDL cholesterol, left ventricular mass, epicardial fat, and carotid intima-media thickness as compared to controls. Total cholesterol, VLDL cholesterol, ventricular diastolic function, epicardial fat, carotid intima-media thickness, carotid local pulse wave velocity, pressure strain elastic modulus, and β arterial stiffness index showed a significant and positive correlation with TSH levels. After one year of replacement therapy, patients with hypothyroidism showed changes in total cholesterol, VLDL cholesterol, TSH, carotid intima-media thickness, and arterial stiffness parameters. CONCLUSIONS Primary hypothyroidism is characterized by an increased cardiovascular risk. In these patients, L-thyroxine replacement therapy for one year is related to decreased dyslipidemia and improvement in markers of subclinical carotid atherosclerosis.
منابع مشابه
Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism
BACKGROUND Previous studies have suggested an association between subclinical hypothyroidism and coronary artery disease that could be related to changes in serum lipids or endothelial dysfunction. METHODS Thirty-two female subclinical hypothyroidism patients were randomly assigned to 12 months of L-thyroxine replacement or no treatment. Endothelial function was measured by the flow-mediated ...
متن کاملAssociation between endothelial dysfunction, epicardial fat and subclinical atherosclerosis during menopause.
BACKGROUND Menopausal transition is critical for the development of early, subclinical vascular damage. Multiple factors, such as atherosclerosis, increased epicardial fat, and endothelial dysfunction can play a role. Hence, the objective of this study was the comparison of epicardial adipose tissue and carotid intima media thickness in order to establish the best predictor of carotid stiffness...
متن کاملAssessing the intima-media thickness and Young modulus changes of the common carotid artery in the neck region external radiotherapy based on the processing of ultrasonic images
Since it is too vital to the prevention of carotid disease in the vascular system, it seems necessary to the estimation of the elastic behavior of the carotid artery in head and neck external radiotherapy. In the present study, a total of 24 neck carcinoma patients treated with external radiotherapy had been studied. The carotid mean dose values were determined for each case by contouring the c...
متن کاملVisceral adiposity and arterial stiffness: echocardiographic epicardial fat thickness reflects, better than waist circumference, carotid arterial stiffness in a large population of hypertensives.
AIMS Relationship between obesity and cardiovascular (CV) disease depends not only on the amount of body fat, but also on its distribution. For example, individuals with increased fat accumulation in the abdominal region have atherogenic lipid profiles and are at increased CV risk. The loss of elasticity in medium and large arteries is an early manifestation of atherosclerosis. The aim of this ...
متن کاملThe evaluation of carotid intima thickness in clinical and subclinical hypothyroidism and effects of thyroid hormone treatment
Objectives: In this study, our aim was to investigate the CA-IMT in clinical hypothyroidism(CH) and subclinical hypothyroidism(SCH) and the effects of L-thyroxine replacement. Materials and methods: The study group consisted of 20 patients with clinical hypothyroidism(CH group) and 20 patients with subclinical hypothyroidism(SCH group) and 20 patients with with normal thyroid hormone function t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion
دوره 62 6 شماره
صفحات -
تاریخ انتشار 2015